Genistein Aglycone


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Genistin, like genistein, is a phytoestrogen as it was shown to stimulate estrogen -dependent breast cancer cell growth in vivo. At a concentration of 1200 ppm , genistin caused significant increase of growth of breast tumors (MCF-7) , cellular proliferation and estrogen-responsive pS2 gene expression in mice . Removal of genistin or genistein from the diet caused tumors to regress. [3]

Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen . It was first isolated in 1899 from the dyer's broom, Genista tinctoria ; hence, the chemical name. The compound structure was established in 1926, when it was found to be identical with that of prunetol . It was chemically synthesized in 1928. [1]



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